Scientist - Protein Sciences

Job Title: Scientist – Protein Purification Team, NBEJob summaryResponsible for planning and executing protein purification and characterization experiments to support molecule screening and evaluation.Conducts hands-on laboratory work, analyzes and interprets data, and presents results in required data management formats.Ensures high standards of data integrity, safety, quality, and compliance while contributing to scientific innovation, process improvement, and platform development.Key responsibilitiesDesign purification strategies based on protein class, structural features, biochemical properties, literature precedent, and existing SOPs.Execute purification workflows hands-on, perform troubleshooting, and optimize conditions to achieve project-specific quality and turnaround requirements.Analyze and interpret protein characterization data to support molecule evaluation and progression decisions.Maintain complete and traceable records in accordance with ALCOA+ principles and internal quality standards.Contribute to laboratory upkeep, training of new team members, and scientific knowledge-sharing activities.Key technical requirementsDownstream processing and protein purification.AKTA-based chromatography and selection of appropriate chromatographic methods for different protein modalities.Protein characterization, including purity assessment, mass spectrometry interpretation, stability profiling, and physicochemical analysis.Purification and handling of challenging targets especially membrane proteins, GPCRs, multi-subunit proteins, and endofree proteins.Inclusion body solubilization and refolding.Process scale-up to gram quantities.Bio-conjugation methods, including cysteine conjugation, lysine conjugation, and linker-based strategies.Desirable:Experience in protein crystallization would be desirable.QualificationsMaster’s degree in Life Sciences or a related discipline.2-7 years of experience in protein sciences with a strong focus on purification and characterization.Strong grounding in protein structure-function relationships, analytical interpretation, and experimental troubleshooting.Working knowledge of safety, quality, and compliance expectations in a discovery laboratory environment.

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