Scientist - Peptide Process R &D

About the jobJob DescriptionJob Title: Scientist - Peptide Process R &D( Proven track record in both SPPS and LPPS is highly desirable)Education & Experience : M.Sc./PhD Organic chemistry with experience on Peptide Process R &D with 3 to 15 years of experience. .1.0 Position SummaryWe are seeking a highly skilled and motivated Research Scientist specializing in peptide chemistry. The ideal candidate will be responsible for the design, execution, optimization, and scale-up of synthetic peptides using both Solid-Phase Peptide Synthesis (SPPS) and Liquid-Phase Peptide Synthesis (LPPS) methodologies. This role requires hands-on expertise in various synthesis techniques, purification, and analytical characterization, as well as a strong commitment to safety, documentation, and project management within a dynamic R&D environment.2.0 Key ResponsibilitiesA. Peptide Synthesis & Development- Design and execute multi-step synthesis of complex peptides (up to 30-40 mers) using manual and automated SPPS techniques. - Demonstrate expertise with a wide range of peptide synthesis resins (e.g., 2-CTC, Rink Amide, Wang, Sieber) and select appropriate resins, protecting groups (Fmoc/Boc), coupling reagents, and solvents for target sequences. - Perform advanced peptide modifications, including disulfide bridging, lactamization, and other cyclization strategies. - Conduct peptide synthesis in solution phase (LPPS) utilizing both Fmoc and Boc protection strategies. - Expertly carry out critical downstream processes, including resin cleavage, global deprotection, quenching, and product isolation.B. Instrumentation & Technology- Operate, troubleshoot, and maintain automated peptide synthesizers. - Utilize microwave peptide synthesizers (e.g., CEM Liberty Blue) to optimize reaction conditions and improve synthesis efficiency. - Conduct synthesis at various scales using manual peptide reactors (1 L to 10 L).C. Purification & Analysis- Purify crude peptides using preparative Reverse-Phase High-Performance Liquid Chromatography (RP−HPLC) and perform subsequent lyophilization. - Interpret analytical data (e.g., HPLC, Mass Spectrometry) to assess reaction progress, purity, and yield, and generate trend data to guide process optimization. - Conduct comprehensive literature surveys to support the development of novel and efficient synthesis strategies.D. Compliance, Safety & Documentation- Maintain meticulous, real-time documentation of all experiments and results in an Electronic Lab Notebook (eLN). - Ensure strict adherence to laboratory safety procedures to prevent incidents and maintain a safe working environment. - Provide technical support for the technology transfer and execution of peptide manufacturing in GMP plant environments. - Ensure timely calibration and proper functioning of laboratory instruments, including analytical balances and pH meters.E. Project Management & Collaboration- Effectively plan and execute projects to ensure timely completion and achievement of R&D milestones. - Engage in regular interaction and coordination with the Cross-Functional Team (CFT), including Analytical, Quality, and Manufacturing departments.

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